SLC2A2 and pancreatic insulinoma: In support of this hypothesis that the cytotoxic effect of STZ is associated with glucose transport capacity, RIN (rat insulinoma cell line) cells, which do not express GLUT2 and express GLUT1 instead, show resistance against STZ toxicity (65 % vs. 87 % and 49 % vs. 81 % cell viability in the presence of 10 mM and 20 mM of STZ for GLUT2-expressing and untransfected RIN cells, respectively) (Schnedl et al., 1994[117]).