It is estimated that 60-70 % of BC patients have at least one mutation in the PI3K/AKT/mTOR pathway, whereas PIK3CA gene, which encodes the p110α subunit of PI3K, is the most frequently mutated gene (Lee et al., 2015[26]; Millis et al., 2019[32]; Xiao et al., 2021[43]). Here, AKT1 is linked to breast cancer.