CASC3 and mantle cell lymphoma: While a phase II HOVON trial was based on administering BTZ as a maintenance therapy after R-CHOP, cytarabine and autologous stem cell transplantation in newly diagnosed patients with mantle cell lymphoma proved no added value for BTZ based on 63 % 5-year event free survival (EFS) versus 60 % 5-year (EFS) in BTZ and placebo group, respectively.