In HCC patients, increased IL-17 and IL-17RE were related to poorer survival and a higher recurrence rate, and Th17 associated cytokines as well as the crosstalk with various kinds of inflammatory or immune cells might suggest how IL-17-producing CD4+T cells promote the carcinogenesis in HCC (Liao et al., 2013). This evidence concerns the gene IL17A and hepatocellular carcinoma.