Mechanistically, miR-181a-5p inhibition regulates cell survival in neurons and astrocytes after forebrain ischemia and stroke (Arvola et al., 2019), and lncRNA SNHG1 promotes neuronal injury in a Parkinson’s disease cell model via the miR-181a-5p/CXCL12 axis (Wang K. et al., 2021). The gene discussed is CXCL12; the disease is stroke disorder.