This open-label, single-arm study investigated the effects of 24 weeks of daily oral administration of the amino acid-based test supplement in addition to standard care on serum IGF-1, a surrogate marker of hGH secretion in individuals with treatment-resistant fibromyalgia and low-normal hGH production (between the 15th and 50th percentile for age-appropriate levels of IGF-1) (13). The gene discussed is IGF1; the disease is fibromyalgia.