CISD1 and breast cancer: Univariate COX regression analysis of 10 HFRS genes showed that BTG1, KRT14, STC2, and TF were protective factors in BC (0< Hazard Ratio (HR)< 1; p< 0.001), while CCT6A, P4HA2, PGK1, TPD52, SLC16A2, and CISD1 were risk factors (HR > 1; p< 0.001) for the overall survival of BC patients (Figure 3A).