In CIBERSORT analysis, the fraction of B_cells_naive, Monocytes, NK_cells_activated, T_cells_CD4_memory_resting, T_cells_CD8, and T_cells_gamma_delta was significantly higher in the low-HFRS group, while Macrophages_M0/M2 and Tregs were significantly lower in the TCGA BC cohort (Figure 6C). Here, CD8A is linked to breast cancer.