We investigated the single nucleotide variations (SNVs) of HFRS genes in different cancers and observed that some genes (CCT6A, TF, KRT14, P4HA2, PGK1, SLC16A2, and STC2) were frequently mutated in COAD, STAD, UCEC, and SKCM (Figure 3C). Here, CCT6A is linked to cancer.