We investigated the single nucleotide variations (SNVs) of HFRS genes in different cancers and observed that some genes (CCT6A, TF, KRT14, P4HA2, PGK1, SLC16A2, and STC2) were frequently mutated in COAD, STAD, UCEC, and SKCM (Figure 3C). The gene discussed is P4HA2; the disease is cancer.