To explore the protein expression of HFRS genes in BC tumor tissues and normal breast tissues, we first collected the immunohistochemical staining images of several HFRS genes from HPA; the protein expression of CCT6A, CISD1, P4HA2, PGK1, TPD52 were higher in tumor tissues than in normal tissues, while KRT14, TF, STC2 were more highly expressed in normal breast tissues (Figure 9A). This evidence concerns the gene CISD1 and neoplasm.