Moreover, several tumor-related pathways and metabolism-related gene sets were enriched in the high-HFRS subgroup, such as CHOLESTEROL_HOMEOSTASIS, MTORC1_SIGNALING, TP53-PTEN related gene sets, MYC targets V1, E2F_TARGETS, PIK3-AKT-MTOR signaling (Supplementary Figures 4D, E–H). This evidence concerns the gene PTEN and neoplasm.