ABCB1 and central nervous system cancer: c-MYC is also involved in regulation of drug resistance in various cancers, such as endometrial cancer, where it induces drug resistance by upregulating the expression of ATP-binding cassette subfamily B member 1 (ABCB1) (19).In glioma stem cells, knocking down c-MYC causes cell cycle arrest and promotes apoptosis, thereby decreasing glioma resistance to drugs (20).