Other molecules, such as FOXA1, SETD2, Hes5, C/EBP-δ, PRMT5, METTL3, Piwil1, PLK1, ERK1/2, and a series of miRNA, indirectly modulate the sensitivity of cancer cells to drugs by regulating FBXW7. The gene discussed is PIWIL1; the disease is cancer.