For example, overexpression of mitochondrial antiviral-signalling protein(Mavs) makes the FBXW7 deficient tumor sensitive to PD-1 blocking, delays the growth of Fbxw7-deficient tumors and prolongs the survival of anti-PD-1-treated Fbxw7-deficient tumor-carrying mice (103). This evidence concerns the gene FBXW7 and neoplasm.