During the last few years, ddPCR has been investigated for the monitoring BCL2::IGH rearrangement in follicular lymphoma (FL), BCL1::IGH in mantle cell lymphoma (MCL), MYD88 mutations in Waldenstrom macroglobulinemia (WM) and IGH rearrangements in chronic lymphocytic leukemia (CLL), proving a promising tool to further refine MRD monitoring (Table 1). Here, MYD88 is linked to mantle cell lymphoma.