Cooperating with members of the TCF/LEF transcription factor family, β-catenin activates a number of target genes including Cyclin D1 (CCND1), cell division cycle 25a (CDC25A), Claudin-7 (CLDN7), vascular endothelial growth factor (VEGF), and matrix metalloproteinase 7 (MMP7), that modulate cell proliferation, metastasis, and tumor progression (1). The gene discussed is VEGFA; the disease is neoplasm.