BRCA1 and breast neoplasm: Little is known about the latter gene but ADAT2 is involved in tRNA modification (42), upregulated through translational control by BRCA1 and a marker of BRCA1 depletion in cell lines and human breast tumors (43), identified as over-expressed in different solid tumors (44), and linked to malignant transformation through its roles in affecting chromatin, transcriptional processes, and apoptosis (44).