The main mechanisms involved in the interruption of the BBB that could be responsible for the severe neurological symptoms in COVID-19 are: (1) hyperinflammation by infection of ECs and surrounding immune cells, which triggers an inflammatory cytokine storm that would lead to the lysis of infected cells; (2) upregulated expression of matrix metalloproteinase-9, which degrades collagen IV, an essential component for basement membrane stability; and (3) activation of RhoA, a small GTPase that induces cytoskeleton restructuring and TJs disassembly. Here, MMP9 is linked to COVID-19.