The latter is a significant issue for ACE2 mediated SARS-CoV-2 Spike-protein association as ACE2 expression is confined to the endothelial cells of the arteries, arterioles, and venules of the heart and kidney to regulate Renin-Angiotensin I-II conversion rendering high blood pressure a risk factor for COVID-19 death. The gene discussed is ACE2; the disease is COVID-19.