CDH1 (shown in Fig. 1F), CST6, MUC1 and SCNN1A genes, all reported to be aberrantly hypermethylated in breast cancer, were down-regulated in both MDA-MB-231 (Fig. S2E) and Hs578T (Fig. S2F) GLO1-depleted breast cancer cells when compared with control. Here, CDH1 is linked to breast carcinoma.