RB1 and cancer: In sum, this upper level of integration selected for six epigenetically repressed pathways included three TSG-A gene sets, the RB pathway and two pathways related to late stages of embryonic stem cell (ESC) differentiation (ESC J1 and ESC V6.5) that are potential suppressors of cancer stem cell phenotype; and three OG-I gene sets, the EGFR and RAF1 main drivers of stem cell and lymphoid enhancer-binding factor 1 (LEF1), as detailed in Data S2.