A regulatory mechanism for this potential tumor suppressor in the inhibition of HIF-2- and eIF4E2-mediated translation activation of oncogenic mRNAs was discovered by other researchers, who found that DDX28 (DEAD Box Protein Family Member) is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation [45]. This evidence concerns the gene INTS6 and neoplasm.