EIF4E3 and central nervous system cancer: EIF4E, EIF4E3, and NCBP2 expression levels were substantially higher in LGG samples compared to healthy brain tissue samples (p < 0.05); whereas the EIF4E2 and NCBP1 expression levels in healthy brain tissues were not statistically significant with the expression in lower-grade glioma tissues (Fig. 9F), which is consistent with the results shown by GEPIA.