When treated with or without the lysosomal inhibitor chloroquine diphosphate (CQ) [27, 28], p62, a receptor for autophagy, were significantly increased in ESCC cells with PSMD2 overexpression and decreased in cells with PSMD2 knockdown when compared with control cells (Fig. 1C, D). The gene discussed is PSMD2; the disease is esophageal squamous cell carcinoma.