Similar to increased copy numbers of ROS1 gene, we know nothing about significance of increased copy numbers of EWSR1 gene in the ES-RMS as well, but find a combination of increased copy numbers of ROS1 and EWSR1 gene, along with high TMB in neoplasm cells, we can reasonably speculate that increased copy numbers of ROS1 and EWSR1, to some extends, may play synergistic functions on the malignant aggression on the background of high TMB in neoplasm cells. This evidence concerns the gene ROS1 and neoplasm.