Rare malignant melanoma can show RMS dedifferentiation, however, it usually presents previous history of melanoma and melanoma in situ and is diffusely positive for S-100, SOX10, HMB45 and Melan A in the classic components of melanoma cells, molecularly, BRAF VE600 mutation can be detected in some melanoma [72, 73]. The gene discussed is MLANA; the disease is melanoma.