EWSR1 re-arrangement was found in a variety of tumors, such as EWSR1-NFATC2 re-arrangement in both simple bone cyst and vascular malformation/hemangioma [57], EWSR1-ATF1 fusion in pediatric mesothelioma [58], EWSR1-CREB3L1 fusion in sclerosing epithelioid fibrosarcoma [59], EWSR1 amplification in clear cell myoepithelial carcinomas [60]. The gene discussed is CREB3L1; the disease is bone disorder.