ES-RMS is a rare neoplasm characteristic by mainly harboring EWSR1-TFCP2 or FUS-TFCP2 fusion, which is mainly distracted from SS-RMS and distinctive from other variants of RMS, such as pleomorphic, alveolar, spindle cell/sclerosing, embryonal RMS. The gene discussed is EWSR1; the disease is epithelioid sarcoma.