Nodular fasciitis is a benign lesion classically arising in the young adults and displays myofibroblast in tissue culture within variable myxoid or collagen-rich stroma, cystic and hemorrhagic space, and a loose storiform growth pattern, along with scattered lymphocytes, plasma cells, osteoclast-like giant cells, it strongly expresses smooth muscle actin but usually neither desmin nor Myo-D1 and Myogenin, more importantly, it is characterized by harboring MYH9-USP6 fusion that lacked in ES-RMS [64, 65]. This evidence concerns the gene MYOD1 and nodular fasciitis.