To determine the role of AVPR2 in HNSCC, we performed GSEA of AVPR2 co-expressed genes in HNSCC and revealed that genes related to AVPR2 expression were significantly enriched in multiple immune-related pathways, including the T-cell receptor signalling pathway, B-cell receptor signalling pathway, antigen processing and presentation, immune checkpoint, and other immune-related pathways. Here, AVPR2 is linked to head and neck squamous cell carcinoma.