Moreover, the Cox proportional hazards analysis showed that receiving the neoadjuvant systemic therapy, lymph node metastasis, Ki67 level ≥ 30%, tumor size > 2 cm and the higher histological grade (grade III) were significantly associated with the inferior prognosis of TNBC patients (Fig. 1C). Here, MKI67 is linked to metastatic malignant neoplasm in the lymph nodes.