The aims of this study were as following: a) to investigate the clinical significance of HER2-low in TNBC patients; b) to delineate the transcriptome patterns of HER2low and HER2neg TNBC; and c) to explore the potential impacts of HER2 status on tumor behaviors and microenvironment properties in TNBC. This evidence concerns the gene ERBB2 and neoplasm.