Traditionally, this differentiation seems to be less pivotal for patients’ clinical treatment options, but recent studies have suggested a potential efficacy of novel HER2-targeted antibody drug conjugates (ADCs) in the treatment of HER2low BC [9, 10], which opens up an emerging era for evaluating the implicit role of HER2-low in the clinical setting of TNBC. The gene discussed is ERBB2; the disease is breast cancer.