Module 1 genes were mainly involved in cell proliferation (CCNK, CCNT1, CETN2, etc.)and DNA damage repair (BLM, HMGB1, FOXM, etc.), which were highly expressed during fate 2, whereas the module 2 genes, mainly elevated during fate 1, were enriched in immune response and tumor migration process, highly expressing TNF, CXCL1, JUN, etc. (Fig. 3I). The gene discussed is HMGB1; the disease is neoplasm.