Importantly, tumor cells in HER2neg TNBC seemed more likely to be associated with activities involving immune responses, highly expressing immunoglobulin-related genes (such as IGKC, IGHG1, IGHG4 and IGLC2) which are associated with the favorable prognosis and have been verified in the clinical TNBC cases. Here, IGHG4 is linked to neoplasm.