PNPLA3 and metabolic dysfunction-associated steatotic liver disease: This is interesting, because Pnpla3 is required for HSC activation (Bruschi et al. 2017) and a genetic variant of PNPLA3 predisposes for development of non-alcoholic fatty liver disease (NAFLD) (Romeo et al. 2008), the pathogenesis of which includes HSC activation (Loomba et al. 2021).