Among the GBM cell lines, LN229 had highest expression of PDIA4, while U87 showed lowest expression (Figure S1D), thus we designed our subsequent experiments using PDIA4-knockdown (sh-PDIA4) LN229 cells and PDIA4-overexpressing (LV-PDIA4) U87 cells. The gene discussed is PDIA4; the disease is glioblastoma.