For example, PDIA3 expression of GBM cells can enhance the pro-tumor ability of macrophage/microglia [11], and knock-out Pdia3 in mice CDD8 + T cells can promote the GBM-killing capacity of T cells in vivo [10]; PDIA4 and PDIA6 contributes to the cisplatin resistance of lung adenocarcinoma [6]; PDIA6 also regulates the EGFR-dependent migratory and invasive abilities of GBM cells [8]. The gene discussed is PDIA4; the disease is glioblastoma.