Furthermore, 59 sera of patients with multiple sclerosis and 50 sera of patients positive for different anti-neuronal autoantibodies (10 × anti-Yo, 10 × anti-Ri, 10 × anti-GAD65, 10 × anti-ITPR1, 10 × Sez6l2) were analyzed using RC-IIFA with HEK293-septin-3/5/6/7/11 complex cells as controls. The gene discussed is ITPR1; the disease is multiple sclerosis.