Moreover, HOTAIR regulates the angiogenesis as well as permeability of blood-tumor barrier via controlling Wnt/b-catenin axis [22] and contributes to biogenesis and the secretion of tumor exosomes [23], the modulation of exosomal miRs [24], and the membrane fusion of exosomes by affecting the colocalization of VAMP3 and SNAP23 via the mTOR-signaling-dependent phosphorylation of SNAP3 [25]. This evidence concerns the gene MTOR and neoplasm.