CD80 and breast cancer: This study also investigated the association between HOTAIR and MALAT1 as regulators, highlighting the regulatory role of MALAT1 and HOTAIR lncRNAs in controlling the tumorigenic activity of TAMs in BC and examining the impact of manipulating MALAT1 and HOTAIR on the expression of CD80 and MSLN in TAMs for HER2 + and TNBC BC.