This study observed that silencing HOTAIR preventes tumor growth in a xenograft model, while the silencing of miR-129-5p reversed HOTAIR gene silencing effects and FZD7 reinstated the inhibitory effect of miR-129-5p, suggesting that HOTAIR regulates the miR-129-5p/FZD7 axis. The gene discussed is FZD7; the disease is neoplasm.