While T (CD3+Ki67) and B (B220+) cells remained unaltered (Extended Data Fig. 1b) in comparison to wild-type (WT) littermate controls (Extended Data Fig. 1c), neutrophils (MPO+) and macrophages (F4/80+) were found to be the dominant immune cell type (Fig. 1g) in the different analyzed organs of the APLAID disease model. This evidence concerns the gene PTPRC and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.