Next, we transferred Plcg2S707Y/+ BM cells into either irradiated WT mice or G-CSF−/− mice (Fig. 7a) to assess if G-CSF originates from hematopoietic or non-hematopoietic cells in our APLAID disease model. Here, CSF3 is linked to autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.