Aside from APLAID, other inherited PLCG2 mutations are identified in phospholipase C gamma 2 (PLCγ2)-associated antibody deficiency and immune dysregulation (PLAID)7, while acquired mutations and variants have been reported in cancer8 and neurodegenerative diseases9. This evidence concerns the gene PLCG2 and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.