We examined if the elevated G-CSF levels in Plcg2S707Y/+ mice are also seen in individuals with APLAID and found increased G-CSF, IL-1β and IL-12p70 in the sera of two treated individuals with APLAID (Fig. 3a)5. Here, IL1B is linked to autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.