TNF and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation: Interestingly, while G-CSF levels in tissue lysates were undetectable, they remained elevated in plasma samples of Plcg2S707Y/+IL-6−/−, Plcg2S707Y/+caspase-1−/− and Plcg2S707Y/+TNF−/− mice, highlighting the superior role of systemic effects over its contribution to the local milieu in our APLAID model.