LAG3 and cutaneous melanoma: In line with this, a phase II and III trial investigated a combination treatment consisting of anti-PD-1 (Nivolumab) together with anti-LAG-3 (Relatlimab) in patients with metastatic or unresectable cutaneous melanoma (NCT03470922) [39], showing a significant increase in progression-free survival for the combination treatment versus Nivolumab alone.