Complete responses (CR), defined in this study as animals that have cleared their tumor(s) and remained tumor-free until the end of the experiment, were observed for all animals receiving PDT treatment combined with either anti-CTLA-4 (Fig. 5c) or with anti-PD-L1 together with anti-LAG-3 (Fig. 5d), with responses lasting up to 60 days post-inoculation. The gene discussed is LAG3; the disease is neoplasm.