SCN8A and Epileptic encephalopathy: Depleting AK057321 strongly downregulates microcephaly gene CDK5RAP2 (human-specific tandem SVA_F, Supplementary Fig. 4) and epileptic encephalopathy gene SCN8A (human-specific SVA_D, Supplementary Fig. 7), as well as several other SVA-containing genes involved in neurogenesis, neuron excitability, synapse and dendrite formation, and mitochondrial function (Fig. 1g).