Given that oxytocin receptors (OTR) are expressed in the mPFC74,75 and receptors activation is required for oxytocin to regulate neurobiological functions, it is possible that activation of the OTR might also be essential for mPFC oxytocin to mitigate epilepsy and cognitive impairments in PTZ-triggered TBI mice. This evidence concerns the gene OXT and Cognitive impairment.