Moreover, from our previous studies of utilizing L-PGDS-ferritin conjugates in AD mice models47 and concentration-dependent disaggregation activity of L-PGDS shown in the ThT assays, we conclude that a significant amount of L-PGDS remains bound to the products of disaggregation thus preventing their re-aggregation as no regrowth of the amyloids was observed (Fig. S17a and S20). This evidence concerns the gene PTGDS and Alzheimer disease.