Low RPA2 was significantly associated with larger tumours, high grade, de-differentiation, pleomorphism, high mitotic index, high Ki67 index, lympho-vascular invasion, lymph node positivity and high-risk Nottingham Prognostic Index (NPI) (all P values ≤0.01) (Supplementary Table 7). The gene discussed is MKI67; the disease is neoplasm.