Low nuclear RPA3 was strongly associated with larger tumours, high grade, high stage, de-differentiation, pleomorphism, high mitotic index, high Ki67 index aggressive breast cancer histological type, lympho-vascular invasion, high-risk Nottingham Prognostic Index (NPI), ER negative, PR negative, triple-negative breast cancers (TNBC) and luminal B breast cancers (all P values <0.001) (Supplementary Table 9). The gene discussed is RPA3; the disease is breast cancer.