RPA2 and ductal breast carcinoma in situ: Low RPA2 was observed in 51% (153/302) of DCIS and it was associated with high nuclear grade (P = 0.007), comedo necrosis (P = 0.009), ER negativity (P = 0.001), PR negativity (P = 0.003) and triple-negative phenotype (P = 0.007) (Supplementary Table 6).