Among the H3K27ac- CTCF sites, one site at ~10 Kb upstream of the MYC gene (hg19, chr8:128737774-128738489; referred to as “−10Kb CTCF site” hereafter) was looped to MYC promoter, and the CTCF binding affinities at this site are negatively correlated with MYC expression levels in PCa cell lines (Fig. 3a, b). This evidence concerns the gene MYC and posterior cortical atrophy.