Neurexin-3 (NRXN3) mutations were found in families with neuropsychiatric disorders44,45, and NRXN3 is a class 1 gene in the SFARI autism gene database (https://gene.sfari.org/database/gene-scoring/), but again how NRXN3 mutations predispose to cognitive impairments is unclear. Here, NRXN3 is linked to autism.