Examination of human cancer tissues has revealed that eIF3d expression is upregulated in many cancers including cancers of breast (54), prostate (55), ovary (56), gallbladder (21), stomach (57), bladder (58), colon (59), lung (60), and cervix (61) as well as in glioma (62), renal cell carcinoma (63), and chronic hepatitis C–associated hepatocellular carcinoma (64). This evidence concerns the gene EIF3D and hereditary clear cell renal cell carcinoma.