Relative to Adv-GFP, either Adv-ATF4 or Adv-NRF2 induced Slc7a11 mRNA in WT and Atf4Δ hepatocytes, but the response to Adv-ATF4 was suppressed in Nfe2l2−/− hepatocytes, a defect that was overcome by Adv-NRF2 infection (Fig. 4F). The gene discussed is ATF4; the disease is infection.