SLC7A11 and infection: Relative to Adv-GFP, either Adv-ATF4 or Adv-NRF2 induced Slc7a11 mRNA in WT and Atf4Δ hepatocytes, but the response to Adv-ATF4 was suppressed in Nfe2l2−/− hepatocytes, a defect that was overcome by Adv-NRF2 infection (Fig. 4F).