The effects estimated by the IVW method showed that a 2-fold increase in serum CRP levels was not significantly associated with the risk of overall or CRC-specific mortality (HD per 1,000 PY: -2.92 and -0.76, respectively; 95% CI, -14.05 to 8.21 and -9.61 to 8.08, respectively). This evidence concerns the gene CRP and colorectal carcinoma.