A meta-analysis of 21 observational studies reported that an elevated preoperative CRP level was associated with poor survival with pooled HRs of 2.04 (95% CI, 1.45 to 2.85) for overall survival and 4.37 (95% CI, 2.63 to 7.27) for CRC-specific survival [12]. This evidence concerns the gene CRP and colorectal carcinoma.