In the combined group of participants who received any dose of Sm-TSP-2/Alhydrogel with or without AP 10–701, moderate systemic symptoms included headache (3/48, 6%), arthralgia (2/48, 4%), nausea (2/48, 4%), vomiting (1/48, 2%), fatigue (1/48, 2%), and myalgia (1/48, 2%). The gene discussed is THBS2; the disease is Myalgia.