To enable in vivo SMN2 C6T conversion in an animal model of SMA, we designed an adeno-associated virus (AAV) strategy to package ABE8e-SpyMac and the P8 sgRNA for delivery (v6 AAV-ABE8e, Supplementary Text, Fig. 3A and fig. This evidence concerns the gene SMN2 and proximal spinal muscular atrophy.