Furthermore, CEBPB was associated with various neoplasms, including leukemia, esophageal squamous cell carcinoma, malignant breast cancer, and lung cancer [50–54] under various patho-mechanisms, such as prevention of cell death and enhancement of self-renewal potential, or as prerequisites for formation of the NRF2-dependent enhancers to enhance tumor-initiating activity [55] and thus drives malignancy in lungs [51]. This evidence concerns the gene CEBPB and esophageal squamous cell carcinoma.