In line with the presence of cholangiocyte-like cells in HB [40, 41], and elevated expression of FGFR2 in bile duct cancer [37, 43, 47, 48], percentages of FGFR2-immuno-positive bile duct cells were the highest in HB tumor region as compared to CC and HB non-tumor livers. This evidence concerns the gene FGFR2 and bile duct cancer.