The associations for end-diastolic volume index, RWT, LVMI, E/e’ ratio, septal e’ velocity, left atrium anteroposterior diameter index, E/A ratio, MAP, and SVRI attenuated after further adjustment for additional confounders and mediators (ie, BMI, alcohol, smoking, MAP, fasting lipids, glucose, insulin, and CRP in addition to age, sex, ethnicity, class, and NEET status) but associations with stroke index and heart rate remained after full adjustment (models 1 and 2, Table 2). The gene discussed is CRP; the disease is Stroke.