The role of Runx2 in remodelling can be directly or via Runx2-related signalling pathways, such as Osterix.36The direct pathway has an involvement of Bone Morphogenetic Protein (BMP) that plays a role in controlling the differentiation of MSCs from progenitors to Runx2.37 Patients with type 2 diabetes mellitus showed a decrease in the amount of Runx2 expression and osteocalcin by 40%. The gene discussed is SP7; the disease is diabetes mellitus.