For instance, several factors contribute to hypertension remission, including gut hormones (peptide YY and glucagon-like peptide-1), resolution of other obesity-related comorbidities that share pathophysiologic mechanisms with HTN (e.g., obstructive sleep apnea), decreases in systemic inflammation leading to reduced arterial stiffness, as well as decreased sodium reabsorption and diminished sympathetic activation [45–48]. This evidence concerns the gene PYY and obesity due to melanocortin 4 receptor deficiency.