The TGF-β superfamily includes several subfamilies of TGF-β, NODAL, growth differentiation factors (GDF), and activating and bone morphogenetic proteins (BMP), which play important roles in embryonic development, body immunity, and cancer (Hayes et al. 2021; Magro-Lopez and Muñoz-Fernández 2021; Stuelten and Zhang 2021). The gene discussed is TGFB1; the disease is cancer.