For classification with regard to genetic disease (Backwell and Marsh, 2022), we suggest that the heterozygous G375R mutation be labeled as an assembly-mediated dominant GOF mutation: assembly-mediated to indicate that mutant and WT subunits assemble into multiple types of functional tetrameric BK channels, dominant because assembled channels with one or more mutant subunits display pathogenic properties, and GOF because less depolarization is required to activate BK channels with one or more mutant subunits. The gene discussed is KCNMA1; the disease is hereditary disease.