In the CardiacMeso-fated segment, Myl7 and Id2 were reduced relative to controls, as was Ankrd1, a gene implicated in sarcomere-binding and dilated cardiomyopathy that is known to be upregulated with overexpression of Mesp1 (Bondue and Blanpain, 2010; Moulik et al., 2009) (Fig. 4E, Table S4B). Here, MESP1 is linked to dilated cardiomyopathy.