SRT1720 is a specific synthetic activator of SIRT1 (silent mating type information regulation 2 homolog 1; Sirtuin 1),[13] PS341 (bortezomib) is a selective proteasome inhibitor that targets the 26S proteasome,[14] and UNC0631 is a potent inhibitor of histone methyltransferase G9a.[15] The inhibitory effect of these three compounds was further confirmed in three MO‐derived meningioma primary cell lines (Figure 6C, Figure S8A,B, Supporting Information). The gene discussed is PRDM9; the disease is meningioma.