HAVCR2 and neoplasm: Tumor cells gradually escape from immune surveillance by shaping an immunosuppressive TIME in its progression and an immunosuppressive TIME promotes tumor growth by various mechanisms including the depletion of tumor-infiltrating T cells, the inhibitory role of immune checkpoint genes such as VISTA, TIM-3 and LAG-3 and inhibitory immune cells like Tregs, TAMs and MDSCs [7].