CD274 and hepatocellular carcinoma: Recent studies revealed that ferroptosis inducers enhanced the efficacy of anti‐PD‐1/PD‐L1 therapy.[13, 38] To examine the potential synergistic effect, orthotopic HCC models were constructed in C57/BL6 mice and randomized to receive single or combination therapy with PK11195 (20 mg kg−1, daily) and anti‐PD‐1 antibody (100 μg, 3 times a week) via intraperitoneal injection (Figure 7E).