This result is consistent with findings reported previously for the P62‐KEAP1‐Nrf2 pathway.[47] In addition, we performed immunohistochemical analysis of clinical specimens to further determine the positively correlated expression of TSPO/P62/KEAP1/Nrf2 in HCC (Figure 5F,G). This evidence concerns the gene KEAP1 and hepatocellular carcinoma.