CGAS and Stroke: Further, the activation of the cGAS-STING pathway could promote the formation of a pro-inflammatory microenvironment and the cGAS-STING expression in microglia was upregulated after stroke (Kong et al., 2022), and conditional knockout of cGAS in microglia attenuates ischemic/reperfusion-induced brain injury (Liao et al., 2020).