The activation of nuclear factor kappa light chain enhancer of activated B cells (NF-κB) in hepatocytes, which is a nuclear transcription factor to regulate the expressions of inflammatory cytokines such as TNFα, interleukin 6 (IL-6), and interleukin 1β (IL-1β), leads to the recruitment and activation of Kupffer cells to mediate inflammation in NASH (88). Here, IL6 is linked to metabolic dysfunction-associated steatohepatitis.