CLOCK and Insulin resistance: In myeloid-specific BMAL1 knockout mice, loss of BMAL1 led to disruption of rhythmic oscillations of clock genes such as ARNTL and nuclear receptor subfamily 1 group D member 1 (NR1D1), increased serum inflammatory cytokines such as IL-1β, IL-6, interferon gamma (INFγ), and monocyte chemoattractant protein-1 (MCP-1), and exacerbated metabolic dysregulation including increased adiposity and insulin resistance (95).