In addition, the interaction between HK2 and voltage‐dependent anion channel can further interfere with the binding between the proapoptotic protein Bax and VDAC, which can escape from mitochondria and trigger apoptosis by forming a channel for cytochrome C. 86In conclusion, HK2 can accelerate the glycolysis rate and inhibit the apoptosis of tumor cells. Here, HK2 is linked to neoplasm.