KDR and Ewing sarcoma: Pazopanib (10), sorafenib (11), regorafenib (12, 13), anlotinib (14) and lenvatinib (15), which all have activity against VEGFR, PDGFR, c-KIT, FGFR and RET, and cabozantinib (16), which targets VEGFR, MET, AXL and RET, have all shown some clinical efficacy in OS and ES patients.